Roles of m⁶A in normal hematopoiesis. In the process of normal hematopoiesis, m⁶A regulators can play promoting (green arrows) or inhibitory (red bars) roles at various stages. Specifically, METTL3 promotes the generation of HSCs, and METTL3 and METTL14 promote the self-renewal activity of HSCs. Another component of the m⁶A writer complex, RBM15, suppresses the transition of long-term HSCs to short-term HSCs. The 3 key subunits of the m⁶A writer complex, METTL3, METTL14, and WTAP, promote erythroid differentiation. In contrast, METTL3, METTL14, and RBM15 inhibit the myeloid differentiation of HSCs in normal hematopoiesis. The m⁶A reader YTHDF2 suppresses the self-renewal activity of HSCs. The identified downstream effectors (signaling pathways and target proteins) or mediator proteins that are critical for the function of m⁶A regulators are listed (in italics). CMP, common myeloid progenitor; HEC, hemogenic endothelial cell.