Roles of m⁶A in myeloid leukemogenesis. In the process of myeloid leukemogenesis, multiple m⁶A regulators play oncogenic roles (green arrows) at different stages of leukemogenesis. METTL3 and METTL14 promote the self-renewal/proliferation of leukemia stem cells/leukemia-initiating cells (LSCs/LICs) and the proliferation/survival of leukemia cells. The RBM15-MKL1 fusion protein plays a role in acute megakaryoblastic leukemia, facilitating the transformation of megakaryocytes and inducing a differentiation bias toward the megakaryocytic lineage. WTAP promotes the proliferation of leukemia cells. FTO and ALKBH5 promote the transformation of HSCs to LSCs/LICs, maintain the self-renewal capacity of LSCs/LICs, and are required for the survival/proliferation of leukemia cells. YTHDF2 is essential for leukemia initiation and the functional integrity of LSCs/LICs. The identified downstream effectors (signaling pathways and target proteins) or mediator proteins that are critical for the function of m⁶A regulators are listed (in italics).