OxPhosi-resistant and OxPhosi-sensitive AML cells in mouse xenograft model. NOD-scid IL2Rγ^null (NSG) mice were injected with 1 million AML PDX cells 24 hours after receiving irradiation at 250 cGy. Mice were randomly assigned to receive vehicle or IACS-010759 (5.0 mg/kg; 5 days on/2 days off until terminal progression) (n = 3 mice per group). Engraftment of the leukemic cells in the peripheral blood was determined by flow cytometry with an anti-human CD45 antibody. OxPhosi-sensitive AML PDXs were from patients 27 to 29; OxPhosi-resistant AML PDXs were from patients 31 to 33. (+) Indicates that only 1 mouse survived . The thick horizontal lines in the bars represent median. Error bars in the graphs show means ± SDs. *P < .05; **P < .01.