Platelet numbers and bleeding time in WT, SMS1-KO, and SMS2-KO mice. (A-C) Complete blood count analyses were performed on whole blood extracted from WT, SMS1-KO, and SMS2-KO mice (n = 3 per group). The numbers of platelets (A), red blood cells (B), and white blood cells (C) in mice of each genotype are shown. (D) The tail vein bleeding times of WT (n = 18), SMS1-KO (n = 12), and SMS2-KO (n = 4) mice are shown. Values show the mean ± standard deviation. *P < .05; **P < .005.