Model of lectin-mediated BCR signaling in DLBCL. Somatic mutations in the IGV region genes of DLBCL (mostly in the complementarity-determining regions) generate motifs for the addition of N-linked glycans. The BCRs carry unusual oligomannose glycans. These can be bound by DC-SIGN and perhaps additional lectins that are expressed by macrophages in the lymphoma microenvironment. Binding of DC-SIGN to the modified BCRs causes signaling that involves phosphorylation of SYK and factors farther downstream, finally leading to activation of ERK and AKT, which have prosurvival effects on the lymphoma cells. Modified from Strout et al.¹⁰ Professional illustration by Patrick Lane, ScEYEnce Studios.