GlcNAc links purine and pyrimidine metabolism to RTK and MAP cascade signaling. (A) Most deregulated metabolic pathways induced by a 24-hour treatment of 20 mM GlcNAc in KIT D816V human MCs. Pathway analysis was performed using MetaboAnalyst 4.0. Each bar represents a pathway, and the color of the bar indicates the P value of the calculated enrichment ratio. (B) Network analysis between the 199 genes in the open region by GlcNAc and the 61 metabolites differentially deregulated par GlcNAc. The 2 subnetworks identified by MetaboAnalyst 4.0 are shown. (C) Integration of the gene pathways and the metabolite pathways deregulated by GlcNAc. Dot color indicates the P value; dot size indicates the number of genes in the pathway.