Schema of the anatomy of the eye and anatomical classification of intraocular lymphoma (IOL). IOL can occur in the uveal tract (iris, ciliary body, and choroid) as a primary (mainly mucosa-associated lymphoid tissue lymphoma) or secondary (to systemic lymphoma) form. IOL that occurs in the vitreous body, the retina, or in rare cases the optic nerve is called vitreoretinal lymphoma (VRL). VRL is subdivided into PVRL, ocular involvement of PCNSL, and secondary lymphoma from systemic diffuse large B-cell lymphoma (DLBCL). The typical localization of lymphoma cells in the case of PVRL is represented by the small yellow circles drawn on the picture. (A) Slit-lamp examination of an eye affected by PVRL showing the infiltration of lymphoma cells in the anterior vitreous and along the vitreous fibrils. (B) Optical coherence tomography (OCT) image of the retina illustrating the infiltration of lymphoma cells into the subretinal space between the retinal pigmented epithelium (yellow arrow) and the Bruch membrane (white arrow) or into the vitreous body.