Cd36^−/− mice generate anti-CD36 antibodies after repeated challenges with wild-type platelets. Breeding the preimmunized females with wild-type males generated placenta dysfunction and a severe FNAIT outcome in the pups. Pooled polyclonal sera and the mAb anti-CD36 identified by hybridoma selection were deglycosylated to remove effector function, to serve as a therapeutic antibody for inhibiting the binding of pathogenic maternal anti-CD36.