Figure 3.
Individual bleeding events after CAR T infusion. Individual plots for each patient with bleeding events illustrating platelet and fibrinogen measurements, as well as platelet and plasma transfusion requirements during the first 30 days after CAR T infusion. Duration and maximum grade of CRS and ICANS are included. Patients are shown in sequential order based on timing of the bleeding event. Note that plots in patients without available fibrinogen measurements (n = 2) do not include gray lines. *Patients treated with a bispecific CD 19/22 CAR construct (n = 2), whereas the remaining patients (n = 10) received CD 19 CAR T therapy with axi-cel. GIB, gastrointestinal bleeding; GUB, genitourinary bleeding; SDH, subdural hematoma.