Forest plot of the association of CALCRL expression on event-free survival in selected subgroups of the pediatric TARGET cohort. Unadjusted hazard ratios (HRs) for high vs low CALCRL expression in selected subgroups are shown. Position of the squares represents the point estimate and horizontal lines represent the 95% confidence intervals (CI). The size of the squares is proportional to the precision of the estimate. The position of the diamond and the dotted vertical line represent the overall HR from the entire cohort. The lateral points of the diamond represent the 95% CI. The P values are for interaction of unadjusted hazard ratios by subgroups and represent heterogeneity. CBF, core-binding factor; CK, complex karyotype; MLL, mixed-lineage leukemia; NK, normal karyotype; NPM1, nucleophosmin-1.