Kaplan-Meier survival curves incorporating ICSS and IPSS-R and time-dependent ROC curves analyzing predictive power of ICSS and IPSS-R, and Kaplan-Meier curves presenting OS of the external validation cohort from GSE15061. (A) OS was well stratified by incorporating ICSS and IPSS-R. (B) ROC curves were estimated by inverse probability of censoring weighting. (C) OS was well stratified by ICSS in the entire patient cohort. (D) Patients with MDS alone, excluding patients with CMML in the GSE15061 cohort. There were no ICSS high-risk patients in the GSE15061 cohort. AUC, area under the curve.