Targeted next-generation sequencing (t-NGS) and multiplex PCR-based clonality results of 82 T-cell lymphoma samples and 25 benign T-cell infiltrates divided into test (N = 57) and validation (N = 50) cohorts. Each column of this plot represents an individual case. Mutated genes are labeled in green and are sorted according to their mutation frequencies; the percentage of mutated cases is provided on the far right. For visualization purposes, only genes mutated in ≥1 case are displayed. Tracks at the bottom of the plot provide data on T-cell clone detection through multiplex PCR assays, on the cohort the case belongs to and on its diagnosis. Color codes are indicated in the key. AITL, angioimmunoblastic T-cell lymphoma; ALK-ALCL, ALK-negative anaplastic large cell lymphoma; ENKTL, extranodal NK/T-cell lymphoma nasal type; FTCL, follicular T-cell lymphoma; γδTCL, γδ T-cell lymphoma; MEITL, monomorphic epitheliotropic intestinal T-cell lymphoma; PTCL NOS, peripheral T-cell lymphoma not otherwise specified; PTCL TFH, peripheral T-cell lymphoma with T-follicular helper phenotype; T-ALL, T-cell acute lymphoblastic leukemia/lymphoma.