Third-party ILC2s improve survival but do not persist. (A) Diagram for B6 into B6D2 transplantation. Each B6D2 recipient received B6 BM and B6 splenic T cells, with one group of B6D2 recipients also being given B10.BR ILC2s. Lethally irradiated B6D2 mice received TCD BM (BM only), BM plus total splenic T cells (BM + T cells), or BM plus T cells with activated B10.BR LC2s (BM, T cells + B10.BR ILC2). (B) Kaplan-Meier plot of survival following allo-HSCT; 1 representative of 2 experiments shown (n = 5 each experiment), log-rank (Mantel-Cox) test. (C) Clinical score posttransplantation, analyzed by using a two-way analysis of variance, with Bonferroni correction for repeated measures of multiple comparisons. Flow cytometry analysis of donor B10.BR (H-2K^k) ILC2 7 days’ posttransplant in the small intestine (D) and lung (E). BMT, BM transplantation.