Figure 3.
Efficacy of third-party ILC2 cells when given therapeutically. (A) Kaplan-Meier plot of B6D2 recipient survival following allo-HSCT, blue arrows indicate time points for B10.BR ILC2 injections for those receiving infusions beginning 7 days posttransplant (Treatment), representative of 2 experiments shown (n = 5 each experiment). Log-rank (Mantel-Cox) test. (B) Clinical score of recipients from panel A, analyzed by 2-way analysis of variance with Bonferroni correction for repeated measures of multiple comparisons P < .05 difference clinical score on days 22-26. (C) Kaplan-Meier plot of B6 recipient survival following allo-HSCT with B10.BR BM and T cells, red arrows indicate time points for BALB/c ILC2 injections for those receiving infusions beginning 7-days posttransplant (Treatment), one representative of 2 experiments shown (n = 7 each experiment). Log-rank (Mantel-Cox) test. (D) Clinical score of recipients from panel C, analyzed by 2-way analysis of variance with Bonferroni correction for repeated measures of multiple comparisons.