Figure 5.
ILC2s suppress aGVHD, in part, through IL-13Ra1 signaling. (A) Diagram for B6 into B6D2 transplantation. Each B6D2 recipient received IL-13Ra1−/− B6 BM and B6 splenic T cells from WT donors, with one group of B6D2 recipients also being given B10.BR ILC2s. Lethally irradiated B6D2 mice received TCD BM (IL-13Ra1−/− BM only), BM plus total splenic T cells (IL-13Ra1−/− BM + WT T cells), or BM plus T cells with activated B10.BR LC2s (IL-13Ra1−/− BM, WT T cells + B10.BR ILC2). (B) Kaplan-Meier plot of survival after allo-HSCT; blue arrows indicate time points for B10.BR ILC2 injections for those receiving infusions beginning at the time of transplant. One representative of 2 experiments shown (n = 5 each experiment), log-rank (Mantel-Cox) test. (C) Clinical score posttransplantation, analyzed by using two-way analysis of variance, with Bonferroni correction for repeated measures of multiple comparisons. (D) Diagram for B10.BR into IL-13Ra1−/− B6 transplantation. Each IL-13Ra1−/− B6 recipient received WT B10.BR BM and B10.BR splenic T cells, with one group of IL-13Ra1−/− B6 recipients also being given BALB/c ILC2s. Lethally irradiated IL-13Ra1−/− B6 mice received TCD BM (BM only), BM plus total splenic T cells (BM + B10.BR T cells), or BM plus T cells with activated BALB/c ILC2s (BM, B10.BR T cells + BALB/c ILC2s). (E) Kaplan-Meier plot of survival after allo-HSCT; red arrows indicate time points for BALB/c ILC2 injections for those receiving infusions beginning at the time of transplant. Representative of 2 experiments shown (n = 5 each experiment), log-rank (Mantel-Cox) test. (F) Clinical score posttransplantation, analyzed by using a two-way analysis of variance, with Bonferroni correction for repeated measures of multiple comparisons.

ILC2s suppress aGVHD, in part, through IL-13Ra1 signaling. (A) Diagram for B6 into B6D2 transplantation. Each B6D2 recipient received IL-13Ra1−/− B6 BM and B6 splenic T cells from WT donors, with one group of B6D2 recipients also being given B10.BR ILC2s. Lethally irradiated B6D2 mice received TCD BM (IL-13Ra1−/− BM only), BM plus total splenic T cells (IL-13Ra1−/− BM + WT T cells), or BM plus T cells with activated B10.BR LC2s (IL-13Ra1−/− BM, WT T cells + B10.BR ILC2). (B) Kaplan-Meier plot of survival after allo-HSCT; blue arrows indicate time points for B10.BR ILC2 injections for those receiving infusions beginning at the time of transplant. One representative of 2 experiments shown (n = 5 each experiment), log-rank (Mantel-Cox) test. (C) Clinical score posttransplantation, analyzed by using two-way analysis of variance, with Bonferroni correction for repeated measures of multiple comparisons. (D) Diagram for B10.BR into IL-13Ra1−/− B6 transplantation. Each IL-13Ra1−/− B6 recipient received WT B10.BR BM and B10.BR splenic T cells, with one group of IL-13Ra1−/− B6 recipients also being given BALB/c ILC2s. Lethally irradiated IL-13Ra1−/− B6 mice received TCD BM (BM only), BM plus total splenic T cells (BM + B10.BR T cells), or BM plus T cells with activated BALB/c ILC2s (BM, B10.BR T cells + BALB/c ILC2s). (E) Kaplan-Meier plot of survival after allo-HSCT; red arrows indicate time points for BALB/c ILC2 injections for those receiving infusions beginning at the time of transplant. Representative of 2 experiments shown (n = 5 each experiment), log-rank (Mantel-Cox) test. (F) Clinical score posttransplantation, analyzed by using a two-way analysis of variance, with Bonferroni correction for repeated measures of multiple comparisons.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal