One-way sensitivity analysis of the most influential variables on the ICER. Tornado diagram of the 10 most influential model variables and their influence on the ICER. Our model was most sensitive to the costs of adverse event-related hospitalizations in either treatment group. However, only the monthly medication costs of oral azacitidine were able to reduce the ICER below a willingness-to-pay threshold of $150 000. Variables were varied by 50% for costs and probabilities and by 10% for utilities as outlined in Table 1. Bars shown in blue and red represent lower and higher costs, respectively.