The heat map of genes mutated in ≥10% of cases in pretreatment circulating tumor DNA. Disease histology and cell of origin are color coded and shown below the heat map. In the heat map, each row represents a gene, and each column represents a primary tumor. The heat map is manually clustered to emphasize mutational co-occurrence. The number and type of somatic mutations in any patient are plotted in the histogram above the heat map, and the number and type of somatic mutations in any given gene are plotted in the histogram on the left of the heat map. The horizontal bar graphs on the right of the heat map show the gene mutation frequency in all cases (red bar), in relapsed FL (turquoise bar), in relapsed DLBCL (violet bar), and in RS (yellow bar).