RNA editome during hematopoiesis. (A) Schematic of the experimental procedure. Briefly, we outlined the RNA editome during hematopoiesis, identified numerous editing events involved in regulating hematopoietic stem and progenitor cells, and explored the underlying mechanisms. (B) The number of editing sites in each population. The A-to-G nucleotide substitution, indicating A-to-I editing, is disproportionately enriched (pie chart) and RNA editing motif. (C) The distribution of editing sites across different genomic elements. (D) The proportion of editing sites within and outside SINEs across different genomic elements; pie chart shows the proportion of editing sites within and outside SINEs. (E) The distribution of RNA editing frequency within each hematopoietic population. (F) The distribution of RNA editing frequency within LT-HSCs (left) and ST-HSCs (right). The color (from blue to red) indicates the editing frequency (from 0 to 1). (G) A dendrogram of hierarchical clustering of editing sites within each population. (H) A co-editing network analysis of 3132 sites detected 13 regulatory modules. The heat map shows the correspondence between cell types and editing modules, which is color-coded as the correlation coefficient (–1 to 1). The tiles are labeled with the P value. Gn, granulocytes; Mφ, macrophages; Mo, monocytes.