Functional relevance of RNA editing in hematopoiesis. (A) A heat map of the editing frequency from 9186 sites that are specially edited in a single population or group or stably edited across 12 populations. The color (from blue to red) indicates the editing frequency (from 0 to 1) for a given site (row) in a population (column) (G2/M indicates cell cycle G2 phase to M phase; SUMOylation indicates that Small Ubiquitin-like Modifier (or SUMO) proteins covalently attached to and detached from other proteins in cells to modify their function). Gray indicates a nondetected editing site. The top 1/2 enriched GO terms are displayed on the right of a given population. (B) A heat map of the RNA editing events within HPC differentiation-related genes. The color (from blue to red) indicates the editing frequency (from 0 to 1) for a given site (row) in a population (column). Gray indicates a missing editing value. (C) Representative examples of group-specific RNA editing sites within hematopoiesis related genes. (D) Representative examples of stage-specific RNA editing sites within hematopoiesis related genes. (E) A summary of the number of editing sites and genes changing at each lineage commitment point. (F) Representative examples of specific editing events within the hematopoietic hierarchy. chr, chromosome; GRAN, granulocyte; MONO, monocyte.