Clinical relevance of CHIP in individuals aged 80 years or older with unexplained cytopenia.(A) Overall survival of subjects with unexplained cytopenia form both the Health_&_Anemia and Monzino_80+ cohorts stratified according to the presence of mutations as ICUS vs CCUS. Probability of survival of individuals without cytopenia was also reported. (B) Overall survival of subjects with CCUS with highly specific mutational patterns for myeloid neoplasms vs CCUS without specific mutational patterns and vs age- and sex-matched patients affected with myeloid neoplasm (myelodysplastic syndromes, from the EuroMDS database).