Unsupervised hierarchical clustering based on gene expression profiles. Hierarchical clustering, oncogene rearrangement identification, PAX5 P80R variant calling, gross chromosome CNV detection, and subtype classification were performed using RNA-seq data. Age, sex, presenting WBC, and CNV of PAX5, CDKN2A/B, and IKZF1 (by MLPA) are shown. These are not used in subtype classification. ITD, internal tandem duplication; NA, not available.