Risk stratification using conventional subtype classification methods compared with RNA-seq. CIR (A) and Kaplan-Meier estimates of OS (B) of risk groups stratified by conventional laboratory tests such as oncogene fusion panels, cytogenetic and DNA index, and risk stratification are limited to BCR-ABL1, KMT2A, and hypodiploid (including near haploid) as HR, and ETV6-RUNX1 and hyperdiploid as LR. CIR (C) and Kaplan-Meier estimates of OS (D) of risk groups on the RNA-seq platform with risk stratification of the new groups recently defined. The LR group includes high hyperdiploid, ETV6-RUNX1, DUX4, and ZNF384-EP300; the HR group includes BCR-ABL1, BCR-ABL1-like, CRLF2, hypodiploid, near haploid, KMT2A, MEF2D, and TCF3-HLF.