FBXO11 is frequently mutated in BL. (A) Bar graph showing the frequency of FBXO11 nonsynonymous mutations in B-cell lymphomas: BL, MZL, and FL. (B) Distribution of FBXO11 genetic alterations in BL. (C) Lollipop plot displaying 57 nonsynonymous FBXO11 mutations identified in BL primary cases (n = 193). Mutations that were functionally validated are shown below the gene model. (D) Mutation status of BL-associated genes in 39 BL cases.²³  The affected genes are reordered in pathways to highlight any mutual exclusivity. Mutations are colored according to the type of SNVs, SVs, and CNAs. Cases are displayed according to the BL subgroups and are annotated with MUM1, BCL2, and SOX11 expression status analyzed by immunohistochemistry, as well as MYC translocation status. BCR, B-cell receptor; CNAs, copy number alterations; DEL, deletion; DUP, duplication; HomoDel, homozygous deletion; INV, inversion; LOH, loss of heterozygosity; n.a., not available; ncRNA, non-coding RNA; SNVs, single nucleotide variants; SVs, structural variants; TRA, translocation.