Cytokine expression in JAK2^+/VF mice upon αTNFR2 treatment. Comparison of serum concentrations of cytokines in untreated JAK2^+/VF mice, untreated JAK2^WT mice, αTNFR2 antibody–treated JAK2^+/VF mice, and IgG-treated JAK2^+/VF mice, as analyzed by Eve Technologies Corporation using a Mouse Cytokine Array/ Chemokine Array 31-Plex. Cytokine concentrations in serum. From left to right: untreated JAK2^WT (n = 4-5), untreated JAK2^+/VF (n = 4-10), αTNFR2 antibody treated JAK2^+/VF (n = 3) and IgG treated JAK2^+/VF mice (n = 3) in serum. Cytokines are depicted in alphabetical order. For statistical analysis, values “red flagged” as “out of range” or “extrapolated values” by Eve Technologies were excluded from the presented data set. Cytokine concentrations are only presented, if the data set of each cytokine consisted of n (values) ≥ 3 after exclusion of “out of range” and “extrapolated” values. *P < .05, **P < .01, ****P < .0001.