Figure 6.
![Gene set enrichment analysis shows increase in IFN-I production in BM pDCs of St3gal1MK−/− mice. (A) Dot plot summarizing Gene Set Enrichment Analysis statistics (P adjusted values [p-adj], normalized enrichment scores [NES], and set size) of IFN and IFN-α/β Reactome pathways comparing combined pDC clusters (1, 2, 11, and 12, also show discretely) with non-pDC clusters. Positive (normalized) enrichment scores indicate increased enrichment in St3gal1MK−/−clusters. (B) Representative enrichment plots of IFN gene sets from combined pDC clusters. (C) A heat map of IFN and IFN-α/β reactome genes of each cluster. KO, knockout; WT, wild type.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/138/23/10.1182_blood.2020008238/3/bloodbld2020008238f6.png?Expires=1735479343&Signature=dIgT4kbNQchjnBVTcdQ50ksxQ3jIxy2d1mRBw7lhdpcOyadUdHXzdkCVlvTBpJVoc7BBQv6Nausc5Eo4nz47H6rrCGgw4XV8tjGRXaIW~zJeQsxvCiKilQ6pqptPdiNnWz2MYeB5uTqoN4gplWlgG4MCTLjklj36Vr-9S8BBFmnGAka5vssShiqrI0p-WGsYaK91ORR-v7lFYcunUWVQ9lrUmHG50rQymLCfnEQXpf21K~DTIMRCULFnTdQPRsUaAZvviOA0f6vROH7TkexmLys3xZCMHmwM8ZZWAEafRnB00tCLidfA00MKtGpYXH0ReLks2CJzOpNU774bEw-auw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Gene set enrichment analysis shows increase in IFN-I production in BM pDCs of St3gal1MK−/− mice. (A) Dot plot summarizing Gene Set Enrichment Analysis statistics (P adjusted values [p-adj], normalized enrichment scores [NES], and set size) of IFN and IFN-α/β Reactome pathways comparing combined pDC clusters (1, 2, 11, and 12, also show discretely) with non-pDC clusters. Positive (normalized) enrichment scores indicate increased enrichment in St3gal1MK−/−clusters. (B) Representative enrichment plots of IFN gene sets from combined pDC clusters. (C) A heat map of IFN and IFN-α/β reactome genes of each cluster. KO, knockout; WT, wild type.