Aggregated reported annualized bleeding rate data for hemophilia A and B clinical trials before (blue) and after (maroon) receiving the described recombinant AAV vectors. The dotted line denotes an annualized bleeding rate of 1.AAV8-wt-FIX, also known as scAAV2/8-LP1-hFIXco. Data from Nathwani et al.⁴⁵  AMT-060 data from Miesbach et al.¹²  AMT-061, now etranocogene dezaparvovec, data from Pipe et al.⁸  SPK-9001, now fidancogene elaparvovec, data from George et al.⁹  BMN270, now valoctocogene roxaparvovec, data from Pasi et al.¹¹  SPK-8011 data from George et al.¹⁴