Longitudinal analysis of risk among selected individuals with and without progression from light chain MGUS to light chain MM.¹⁹  A risk score was developed to evaluate and label individual blood samples as follows: low-risk light chain MGUS, 0 to 1 (gray); intermediate-risk light chain MGUS, 2 (white); high-risk light chain MGUS, 3 or higher (orange). Each series of boxes represents a unique patient, each box represents a unique blood sample, and the x-axis represents number of years before MM diagnosis (for case patients) and number of years before selection (for controls). Each box includes a number that represents the risk score. LMG indicates nonprogressing light chain MGUS, and LMM indicates progressing from light chain MGUS to light chain MM. ^aFulfilled the blood-based criteria for MM (ie, FLC ratio ≥100 and involved FLC concentration ≥10 mg/dL). Reprinted by permission, Landgren et al, JAMA Oncol, 2019.¹⁹