General guidelines for management of ICANS. Frequent neurologic assessments, multidisciplinary supportive care, and glucocorticoids form the backbone of ICANS management. In addition, several novel strategies are being studied for refractory ICANS, as described in the text. ATG, anti–thymocyte globulin; CRP, C-reactive protein; EVD, external ventricular drain; ICU, intensive care unit; LP, lumbar puncture; NPO, nothing by mouth.