Category of aggressive B-cell lymphomas “HGBLs with MYC and BCL2 and/or BCL6 rearrangements” described in the 2016 revision to the World Health Organization classification of tumors of hematopoietic and lymphoid tumors. Most cases with MYC and BCL2 rearrangements are of GCB origin, whereas most cases with BCL6 rearrangements are of ABC origin. This category includes DH lymphomas, which involve MYC and BCL2 or MYC and BCL6, as well as THLs that involve MYC, BCL2, and BCL6. When translocated, MYC may have an IG or non-IG partner gene, with the former associated with an inferior outcome. In a large study, 7.9% of tumors with DLBCL morphology were assigned to HGBL-DHL/THL, composing 13.3% of GCB and 1.7% of ABC DLBCL.³⁰