![Dual anti–TNF-α and IL-6R blockade mitigated acute GVHD without interfering with the graft-versus-tumor effect in two different mouse models (major histocompatibility complex [MHC]–mismatch model BALB/c into C57BL/6 and minor mismatch model B10.D2 into diet-induced obese [DIO] BALB/c recipients). Professional illustration by Patrick Lane, ScEYEnce Studios.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/138/24/10.1182_blood.2021013772/5/bloodbld2021013772cf1.png?Expires=1735497835&Signature=i2~nH6FxnL9aopCqD27kwlCJ4u8K3L7Zc5yiv~FmtZyRMvvYVlJAxn~XRvJ7e8GIeIvbZNysn0FFVH0rSC63OZsdE2VP2o7OH4jypVuVI8Lu8bIjj5Rk2yvBdvD~ssxJGyDPmpYAxZ9R3liSyOfJQVdMb~nBimBziv1p6uRliAUg5qPqAQ~FD7lIwoFdzvHaMA9KyDCE2~YzxRFEEeX0j16aILdQv3-H0CtBczPFej-1ApnT12EgLtYYU5tkUaE~EcB2g8REWVN4KYBUkEq7j5mOJI~euh0ZFlj4Adu75knm2EncQ0PkXI8Jc-BGLwXkX8ILVpsrwXptZqPJ1vukkQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Dual anti–TNF-α and IL-6R blockade mitigated acute GVHD without interfering with the graft-versus-tumor effect in two different mouse models (major histocompatibility complex [MHC]–mismatch model BALB/c into C57BL/6 and minor mismatch model B10.D2 into diet-induced obese [DIO] BALB/c recipients). Professional illustration by Patrick Lane, ScEYEnce Studios.