The impact of the CAR-HEMATOTOX score on concurrent immunotoxicity, clinical outcomes, and the duration of hospitalization. Comparison of (A) CRS and (B) ICANS severity according to American Society for Transplantation and Cellular Therapy (ASTCT) grading among patients with a low or high CAR-HEMATOTOX score. Kaplan-Meier estimates of (C) PFS and (D) OS according to CAR-HEMATOTOX score. (E) Comparison of the overall response rate (ORR) as assessed by positron emission tomography/computed tomography staging on day 90 according to Lugano criteria. In all, 10 of 15 patients with a low CAR-HEMATOTOX score showed evidence of response (complete response [CR], 8; partial response [PR], 2) compared with 9 of 25 patients with high CAR-HEMATOTOX score (CR, 6; PR, 3). (F) Duration of hospitalization from lymphodepletion until discharge or death by CAR-HEMATOTOX score and by severity of hematotoxicity. Severe hematotoxicity was defined as severe neutropenia for ≥14 days between days 0 and 60. Error bars indicate the standard error of the mean (SEM). P-values were determined by Mann-Whitney U test.