Comparison of DNA methylation and gene expression between HM_DREAM and LM_DREAM profiles. (A) Starburst plot represents the relationship between gene expression levels from transcriptome analysis and DNA methylation levels at 7360 CpG sites used for clustering classification of DREAM among HM_DREAM (n = 32) and LM_DREAM (n = 46) subgroups. Log₁₀ (false discovery rate (FDR)–adjusted P value) was plotted for DNA methylation (x-axis) and gene expression (y-axis) for each gene. In case of a higher mean DNA methylation ratio or mean gene expression value, −1 was multiplied to log₁₀ (FDR-adjusted P value) to provide positive values. The dashed black lines indicate FDR-adjusted P values at 0.05; the red points indicate genes that are significantly upregulated and LM; the green points indicate genes that are significantly downregulated and HM. (B) Starburst plot was evaluated for 84 CpG sites used in the SVM model.