Predictive value of baseline variables for favoring IC or ven/aza. (A) Factors that favored the likelihood of achieving a response (CR or CRi) to IC vs ven/aza. RUNX1 mutation plus age ≥65 years was assessed but not estimable. (B) Factors that favored OS for IC compared with ven/aza. (C) In a cohort of patients propensity matched for age, ELN risk group, and transplantation status, factors that favored OS for IC vs ven/aza. Variables that were assessed but not estimable included NPM1 mutation plus age ≥65 years and RUNX1 mutation plus age ≥65 years.