![Multivariate analysis of relapse influencing variables and impact of pre-HCT serostatus constellation. (A) Patient cohort without ATG (n = 420). Multivariate analysis of relapse as time-dependent endpoint. Forest plots showing results from multivariate analysis including all significant covariates from univariate analysis with respect to relapse. (B) Patient cohort with ATG (n = 267). Multivariate analysis of relapse as time-dependent endpoint. Plots as in panel A. (C) Cumulative relapse incidence depending on CMV serostatus without ATG and (D) with ATG. Cumulative incidence function of relapse (60 months censored) compared by CMV serostatus (R+/D+ [blue], R+/D− [red], R−/D+ [green], and R−/D− [brown]. Median [line] with 95% CI shaded). C+D: P values according to Gray’s test. Abbreviations: GVHD, graft-versus-host disease; HLA, human leukocyte antigen; MAC, myeloablative conditioning; PBSC, peripheral blood derived stem cells.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/6/1/10.1182_bloodadvances.2021005509/3/advancesadv2021005509f2.png?Expires=1736045916&Signature=1f5IZt7C9oDXL-U~rMXtpx3fY6fVKPdsgtYzOYurJJvmjFqhFzt9Cd7FswY~L4EmyRx1KBZ3nCs5ZOq9YgbbK9NsplCf3Dy0m7WDtw3FKm7unmNlxiCQWGaFJ1rMI9x5lKsNPFZW1i~ZaG-7nin0eNMxam089sp23HSx0ltkOP9scvwWfA3KAMfXvbW~T2sLvmV2U~qKZNhWyykMPNW9UHyk8GXArRhhQxQj-Fhpo-Tj6cQow3HcCyfZ~YvkK5Lb3svTtl3nwc6z4HQYI4XcBH1royR9~Zi3B46~RUShuKp9BSTXOLIL1cdFBvpSWegP7Lm5HZtIfJ3bIlNle77CBg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Multivariate analysis of relapse influencing variables and impact of pre-HCT serostatus constellation. (A) Patient cohort without ATG (n = 420). Multivariate analysis of relapse as time-dependent endpoint. Forest plots showing results from multivariate analysis including all significant covariates from univariate analysis with respect to relapse. (B) Patient cohort with ATG (n = 267). Multivariate analysis of relapse as time-dependent endpoint. Plots as in panel A. (C) Cumulative relapse incidence depending on CMV serostatus without ATG and (D) with ATG. Cumulative incidence function of relapse (60 months censored) compared by CMV serostatus (R+/D+ [blue], R+/D− [red], R−/D+ [green], and R−/D− [brown]. Median [line] with 95% CI shaded). C+D: P values according to Gray’s test. Abbreviations: GVHD, graft-versus-host disease; HLA, human leukocyte antigen; MAC, myeloablative conditioning; PBSC, peripheral blood derived stem cells.