Simulated structural divergence between each class II risk allele and the pool of alleles present in DRB1 and DQB1 loci in patients and controls. (A) Circle graph representing the simulated divergences between DRB1*15:01 and each allele present in DRB1 locus of IAA/PNH patients and HC. Red bars illustrate the alleles more similar to DRB1*15:01 (divergent pairs located under the twenty-fifth percentile cutoff of the simulated distribution). (B) Forest plots showing the results of the binomial logistic regression analysis predicting the association between the presence of DRB1*15:01-like alleles and AA “immune-enriched” phenotypes. HCs (n = 960) were used as a comparator group. Pie charts describe the distribution of alleles more similar and more divergent from DRB1*15:01 in patients and controls. All (n = 263); IAA responders (n = 140); IAA >20 years (n = 216); IAA with PNH clones (n = 135); IAA >20 years with PNH clone and responders (n = 59). (C) Circle graph representing the simulated divergences between DQB1*06:02 and each allele present in DQB1 locus of IAA/PNH patients and HC. Red bars illustrate the alleles more similar to DQB1*06:02 (divergent pairs located under the twenty-fifth percentile cutoff of the simulated distribution). (D) Forest plots showing the results of the binomial logistic regression analysis predicting the association between the presence of DQB1*06:02-like alleles and an IAA “immune-enriched” phenotype. HCs (n = 960) were used as a comparator group. Pie charts describe the distribution of alleles more similar and more divergent from DQB1*06:02 in patients and controls.