The impact of initial response and late events on survival in EPAG-IST group. (A) All-cause mortality was included. There was no statistical difference in overall survival in EPAG-IST and historic IST group. (B) Patients with relapse did not have a worse outcome when compared with the ones without a relapse (this group includes patients with clonal evolution). (C) High-risk clonal evolution resulted in lower survival when compared with patients with no evolution or low-risk evolution. (D) Patients who did not achieve the initial hematologic response (non-responders) had poorer overall survival when compared with the ones with the response; however, achieving a complete response did not further improve the survival when compared with the patients with incomplete recovery.