Utility of BLEAT for diverse applications. The assignment of the leader genotype to the HLA-B allele may be useful for downstream applications by HLA laboratories, clinical researchers, donor registries, cell source banks, and health care workers. For HLA laboratories involved in basic research, these include exploration of allele diversity and haplotype linkage involving HLA-B to examine HLA structure and function. Laboratories may also supply this information for clinical research pursuits in understanding historical patient risk or modeling future risk to improve outcomes. Health care workers can apply BLEAT toward the selection of optimal donors based on transplant risk that can also be facilitated by donor registries or cell source banks. The assessment of HLA-B allele diversity can also aid in ensuring that therapies are available for diverse populations and enable individualized treatment.