Association of ASNS methylation status with therapeutic outcome in childhood T-ALL. (A) Comparison of ASNS methylation status between refractory/relapsed cases and non-refractory/relapsed cases in childhood T-ALL. Red, yellow, and blue columns indicate ASNS highly methylated (>66.7%), intermediately methylated (33.3%-66.7%), and weakly methylated (<33.3%) cases, respectively. The P value in the χ² test is shown. Kaplan-Meier plots of EFS (B) and OS (C) in childhood T-ALL stratified according to percent methylation of ASNS gene. The prognoses of ASNS highly methylated (>66.7%; red), intermediately methylated (33.3% -66.7%; yellow), and weakly methylated (<33.3%; blue) cases were compared. The P values in the log-rank test are shown.