Impact of pubertal status on metabolic biomarker patterns at onset of cGVHD. Subjects were divided into (A) prepubertal and (B) pubertal based on previously published criteria.¹⁶ We compared the plasma samples at the onset of cGVHD in (A) prepubertal subjects with cGVHD to prepubertal subjects who did not develop cGVHD, and (B) pubertal subjects with cGVHD to pubertal subjects who did not develop cGVHD. The identical identifying metabolic color code and selection criteria as in Figure 1 were used in this figure.