p53 haploinsufficiency abolishes the protective effect of PARP-2 deficiency in the development of B lymphomas in Eμ-Myc^T/+ mice. (A) Kaplan-Meier curves comparing B-cell lymphoma–free survival of Eμ-Myc^T/+Parp-2^+/+p53^+/− and Eμ-Myc^T/+Parp-2^−/−p53^+/− mice. (B) Bar graph displaying absolute number of total, pre-B, immature (ImmB), and mature (MatB) BM B cells in Eμ-Myc^T/+Parp-2^+/+p53^+/− and Eμ-Myc^T/+Parp-2^−/−p53^+/− mice. (C) Graph showing the percentage of BM pre-B cells for each genotype in G₀, G₁, S, and G₂/M phases of the cell cycle. (D) Bar graph showing the percentage of cells positive for active caspase-3 for each genotype. Values represent mean ± SEM obtained from at least 6 mice per genotype.