Impact of CMV gastroenteritis and letermovir on NRM. Simon-Makuch plots for the effect of CMV reactivation and gastroenteritis on NRM (A) and the adjusted cumulative incidence of NRM in patients with and without letermovir prophylaxis (B). Adjusted curves were plotted with the following covariates: recipient’s age at HCT, sex mismatch, CMV serological status, disease, DRI, KPS, HCT-CI, donor source, conditioning intensity, GVHD prophylaxis, in vivo T-cell depletion, year of HCT, organ involvement sites of aGVHD, and use of systemic steroids.