Patients with pES share similar immunophenotype irrespective of genetic and immunoglobulins status. Patients with pES were categorized based on the presence or absence of genetic abnormalities. Plots showing percentage of cTfh (A), CD4⁺ naïve (B), CD4⁺ T‐cell activation (C), and CSMB (D) in 2 pES groups based on underlying genetics. Plots showing percentage of cTfh (E), CD4⁺ naïve (F), CD4⁺ T‐cell activation (G), and CSMB (H) in patients with pES with normal/high and low IgG levels. Patients with pES were also categorized based on serum IgA levels. Plots showing frequency of cTfh (I), CD4⁺ naïve (J), CD4⁺ T-cell activation (K), and CSMB (L) in patients with pES with low serum IgA or normal/high IgA levels. Data represent mean ± SEM values for each group. Mann-Whitney test for nonparametric samples and Student t test for parametric samples were performed for significance. *P < .05; ns, not significant.