Figure 7.
Comparison of TCR-β repertoire of cTfh population in patients with pES and HCs. (A) Representative images of tree maps showing diversity of TCR repertoire in patient with pES and HC. (B) Bar graph showing clonal proportion of TCR-β for top 0 to 10, 11 to 50, 51 to 100, 101 to 200, 201 to 400, and >400 clones. (C-E) Violin plots showing TCR repertoire diversity in terms of Shannon’s entropy, diversity index, and Gini coefficient in samples from patients with pES (n = 4) and HCs (n = 4). (F) Plots showing percentage use of TRBV29-1 in samples from patient with pES (n = 4) and HCs (n = 4). (G) Venn diagram of unique TCR-β aa sequences in samples from patients with pES (n = 4) and HCs (n = 4) showing overlap of TCR repertoire among samples. (H) List showing CDR3 aa sequences shared within patients with pES and HCs, as well as between patients with pES and HCs.