Genomic and mutational landscape in plasmablastic lymphoma. (A) An oncoplot of genes mutated in at least 3 PBL samples after PBL MutSigCV analysis (P < .05) with allele frequencies added (left bar) and samples affected (right bar). Different types of mutations are color coded. In addition, covariates are shown below the plot for each sample. EBV-encoded RNA [EBER] EBV/HIV: neg, negative; pos, positive. MYC fluorescence in situ hybridization (FISH): ab, aberrated; NA, not available; wt, wild type. Progress: PD, progression disease; R, remission; SD, stable disease. (B) Location of SCNVs along the genome (red bars denote gains; blue bars denote losses; gene names refer to affected oncogenes and genes related to oncogenetic pathways). (C) Selected genes (oncogenes and oncogenetic pathway genes) affected by SCNVs.