Figure 5.
![Distinctive expression pattern between EBV+ and EBV– PBL. (A) Volcano plot shows log2 fold-change (FC) and q-values of expression analysis (limma: EBV positive [EBV+] vs EBV negative [EBV–]; positive log2 FC refer to upregulated genes in EBV+, negative values to upregulated genes in EBV–). Genes related to NF-κB, PI3K AKT TOR, IL6 JAK STAT3, RTK_RAS, and NOTCH pathways are shown. Genes from Dunmire et al66 are also included. (B) Gene set enrichment analysis against Gene Ontology gene sets on differentially expressed genes (log2 fold-change > 1, padj < 0.01). Results were manually curated (full list is shown in supplemental Figure 9); enrichment scores (length of bar) and log scaled q-values (color-coded dots) are displayed.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/6/2/10.1182_bloodadvances.2021005486/4/advancesadv2021005486f5.png?Expires=1736045614&Signature=GFnajlPUJaASZ03F-dd64llH6Iec8Z81ZrcZYPiqDCcjYMAQJbj6yxUpMCV97BcD6CyQkH5RN2-wqU8Qe80xfQ1fKD0U4139FBu9JTdrPceOtWtYeoZewpc9RQC-SA1COVsfgIeqpU3wmsACsooTbbg79~42IJZ0MKTrxm2t5OHJO3niHQTf1xEhEmpjDPUifiNYriwGY2oZBc9BQSuaPY5gl~bR7PMssfosEY2ws1CA-nzTAWPtd8D-jpyHMxm40UQT2-oQAYwEnTzb~1AfxHmiPOtAEQS665NnHSQsSXeH1pJIq2290X5TAlxmC-mD-q8tLLoVmr~-RL6nGgh2PQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Distinctive expression pattern between EBV+ and EBV– PBL. (A) Volcano plot shows log2 fold-change (FC) and q-values of expression analysis (limma: EBV positive [EBV+] vs EBV negative [EBV–]; positive log2 FC refer to upregulated genes in EBV+, negative values to upregulated genes in EBV–). Genes related to NF-κB, PI3K AKT TOR, IL6 JAK STAT3, RTK_RAS, and NOTCH pathways are shown. Genes from Dunmire et al66 are also included. (B) Gene set enrichment analysis against Gene Ontology gene sets on differentially expressed genes (log2 fold-change > 1, padj < 0.01). Results were manually curated (full list is shown in supplemental Figure 9); enrichment scores (length of bar) and log scaled q-values (color-coded dots) are displayed.