When Funk et al compare control CART cells with CART cells that have been treated with the PI3Kδ/γ inhibitor duvelisib (eg, duv-CAR), they find increased levels of exhaustion markers TIM-3 and LAG-3 in the control CART cells and increased proliferation, mitochondrial fusion proteins MFN1 and MFN2, and a more stem-like phenotype of the duv-CAR.