Distribution of CTMCs in blood of healthy donors and patients with MCAS, CM, or SM. Patients were classified according to (A-C) WHO diagnostic disease categories and (D) GPSM-PFS and (E) advanced SM (AdvSM)-IPSM risk stratification models. In each panel, boxes extend from the 25th to the 75th percentiles; the horizontal line in each box corresponds to the median value and vertical lines denote the 5th and 95th percentiles. In addition, the percentage of CTMC⁺ (ie, ≥10 CTMCs per mL) patients per diagnostic category is shown along the top of each panel. HD, healthy donor; Inter, intermediate; MCL, mast cell leukemia; PB, peripheral blood.