Survival of patients with hTTP. The survival data are from 221 patients, excluding 5 patients for whom the duration of follow-up was not reported. (A) The probability of survival of the patients with hTTP (green line) was compared with the age- and sex-matched US population (red line) values using Kaplan-Meier methods. The difference between the patients with hTTP and the expected deaths in the US population was determined by using 95% CIs for the patients’ deaths (blue lines). Beginning at birth, the 95% CIs did not overlap with the survival line for the US population. (B) The probabilities of survival of male and female patients with hTTP were calculated separately by using Kaplan-Meier methods and a log-rank test to determine differences. The 95% CIs are illustrated by blue for female and red for male.