Efficacy of sequential CAR T-cell infusions in 10 patients with CNS involvement. (A) CD19 CAR T-cell expansion in the cerebrospinal fluid (CSF) of 10 patients with CNS involvement. (B) The MRI scans demonstrate that the mass beneath the leptomeningeum of P16 disappeared completely after mCD19 CAR T-cell infusion. (C) PFS after sequential CAR T-cell infusion. The median PFS rate was not reached; the estimated 18-month PFS rate was 60% (95% CI, 25%-83%) in patients with CNS involvement, which was not significantly lower than that in patients with no CNS involvement (P = .28).