Figure 2.
Enhanced GVHD in Ifnlr1−/− recipients is dependent on signaling in hematopoietic and nonhematopoietic cells. (A) Transplant schema for creation of BM chimeras and secondary transplants. (B) Representative images of colon at day 7 post-BMT. (C) Semiquantitative colon GVHD histopathology scores at day 7 post-BMT (n = 11 for WT → WT and WT → Ifnlr1–/–, n = 15 for Ifnlr1–/– → WT and n = 14 for Ifnlr1–/– → Ifnlr1–/–, combined from 2 experiments). (D) Serum IFN-γ and IL-6 at day 4 post-BMT. (E) Quantitative polymerase chain reaction enumeration of Ifnlr1 transcripts from naive WT homogenized tissue normalized to expression in liver (n = 3). Data are presented as mean ± SEM. P values were calculated by using analysis of variance and Tukey’s multiple comparison. *P <.05, **P < .01, ***P < .001, ****P < .0001.

Enhanced GVHD in Ifnlr1−/− recipients is dependent on signaling in hematopoietic and nonhematopoietic cells. (A) Transplant schema for creation of BM chimeras and secondary transplants. (B) Representative images of colon at day 7 post-BMT. (C) Semiquantitative colon GVHD histopathology scores at day 7 post-BMT (n = 11 for WT → WT and WT → Ifnlr1–/–, n = 15 for Ifnlr1–/– → WT and n = 14 for Ifnlr1–/– → Ifnlr1–/–, combined from 2 experiments). (D) Serum IFN-γ and IL-6 at day 4 post-BMT. (E) Quantitative polymerase chain reaction enumeration of Ifnlr1 transcripts from naive WT homogenized tissue normalized to expression in liver (n = 3). Data are presented as mean ± SEM. P values were calculated by using analysis of variance and Tukey’s multiple comparison. *P <.05, **P < .01, ***P < .001, ****P < .0001.

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